LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders?
نویسندگان
چکیده
منابع مشابه
LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders?
Leucine rich repeat proteins have gained considerable interest as therapeutic targets due to their expression and biological activity within the central nervous system. LINGO-1 has received particular attention since it inhibits axonal regeneration after spinal cord injury in a RhoA dependent manner while inhibiting leucine rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO-...
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Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions. Although playing a major role in developmental brain functions, the...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2017
ISSN: 1673-5374
DOI: 10.4103/1673-5374.213538